Macrocyclization strategies for cyclic peptides and peptidomimetics
نویسندگان
چکیده
Macrocyclization between head, tail or sidechains is a frequently employed strategy to enhance peptide and peptidomimetic stability, selectivity affinity.
منابع مشابه
Contemporary strategies for peptide macrocyclization.
Peptide macrocycles have found applications that range from drug discovery to nanomaterials. These ring-shaped molecules have shown remarkable capacity for functional fine-tuning. Such capacity is enabled by the possibility of adjusting the peptide conformation using the techniques of chemical synthesis. Cyclic peptides have been difficult, and often impossible, to prepare using traditional syn...
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Helma Wennemers HW received her master (Diploma) degree in chemistry from the University of Frankfurt in 1993 and her PhD degree from Columbia University New York in 1996. After two years as a postdoctoral researcher at Nagoya University, she joined the faculty at the University of Basel where she is now associate professor of chemistry. Her research focuses on the use of peptides in supramolec...
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A glutathione S-transferase (GST) catalyzed macrocyclization reaction for peptides up to 40 amino acids in length is reported. GST catalyzes the selective S(N)Ar reaction between an N-terminal glutathione (GSH, γ-Glu-Cys-Gly) tag and a C-terminal perfluoroaryl-modified cysteine on the same polypeptide chain. Cyclic peptides ranging from 9 to 24 residues were quantitatively produced within 2 h i...
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ژورنال
عنوان ژورنال: RSC medicinal chemistry
سال: 2021
ISSN: ['2632-8682']
DOI: https://doi.org/10.1039/d1md00083g